AUTOIMMUNITY IN VITILIGO - RELATIONSHIP WITH HLA, GM AND KM POLYMORPHISMS

被引：37

作者：

LORINI, R

ORECCHIA, G

MARTINETTI, M

DUGOUJON, JM

CUCCIA, M

机构：

[1] Clinica Pediatrica, Universita di Pavia

[2] Clinica Dermatologica, Universita di Pavia, Pavia

[3] Laboratorio HLA, Centro Trasfusionale AVIS, Pavia

[4] Centre de Recherches sur le Polymorphisme Genetique des Populations Humaines (CRPG-CNRS), Hopital Purpan, Toulouse

[5] Dipartimento di Genetica e di Microbiologia, Universita di Pavia, Pavia

来源：

AUTOIMMUNITY | 1992年 / 11卷 / 04期

关键词：

VITILIGO; AUTOANTIBODIES; HLA POLYMORPHISMS; GM AND KM ALLOTYPES;

D O I：

10.3109/08916939209035163

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71% in particular anti-parietal cells (26.6% antithyroglobulin (24.4% and antithyroid microsomal antibodies (43% One patient was also affected by Hashimoto's thyroiditis, 4 by Graves' disease and two others by nontoxic, multinodular goiter. No correlation was found between chronologic age and sex and the presence of autoantibodies, while an increased frequency of organ-specific autoantibodies was found with longer duration of vitiligo. HLA-A3 and Gm (3; 23; 5, 10, 11, 13, 14) phenotype frequencies were significantly increased in patients without autoantibodies (P<0.05). Patients negative for these two phenotypes were significantly more prone to develop autoantibodies than those positive (P=0.0032). C4AQO allele showed a significantly decreased frequency in the whole group of patients when compared to the controls (P<0.05). © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：255 / 260

页数：6

共 31 条

[1]

Brostoff J., Bor S., Fciwel M., Autoantibodies in patients with vitiligo, Lancet, 2, pp. 177-178, (1969)

[2]

Korkji W., Solatani K., Simjee S., Marcincin P.G., Chu-ang T., Tissue specific autoantibodies and autoimmune disorders in vitiligo and alopecia areata: a retrospective study, J Cut Pathol, 11, pp. 522-530, (1984)

[3]

Betterle C., Caretto A., De Zio A., Pedini B., Veller-Fornasa C., Cecchetto A., Et al., Incidence and significance of organ‐specific autoimmune disorders (clinical, latent or only autoantibodies) in patients with vitiligo, Dermatologica, 171, pp. 419-423, (1985)

[4]

Bystryn J.C., Immune mechanisms in vitiligo, Immune Mechanisms in Cutaneous Disease, pp. 447-473, (1989)

[5]

Bystryn J.C., Serum antibodies in vitiligo patients, Disorders of pigmentation. Clinics in dermatology, 7, pp. 136-145, (1989)

[6]

Hertz K.C., Gazze L.A., Kirkpatrick C.H., Katz S.I., Autoimmune vitiligo: Detection of antibodies to melanin‐producing cells, N Engl J Med, 297, pp. 634-637, (1977)

[7]

Naughton G.K., Eisinger M., Bystryn J.C., Detection of antibodies to melanocytes in vitiligo by specific immunoprecipitation, J Invest Dermatol, 81, pp. 540-542, (1983)

[8]

Betterle C., Mirakian R., Doniach D., Bottazzo G.F., Riley W., MacLaren N.K., Antibodies to melanocytes in vitiligo, Lancet, 1, (1984)

[9]

Grimes P.E., Mamdooh G., Stockton T., Payne C., Kelly P., Alfred L., T cell profiles in vitiligo, J Am Acad Dermatol, 14, pp. 196-201, (1986)

[10]

Mozzanica N., Frigerio U., Finzi A.F., Cattaneo A., Negri M., Sca-glione F., Et al., T cell subpopulation in vitiligo: a chronobiol‐ogic study, J Am Acad Dermatol, 22, pp. 223-230, (1990)

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