HYDROGEN-BONDS BETWEEN CHOLESTEROL AND OXYGEN BASES - A THERMODYNAMIC STUDY

被引:18
作者
GORALSKI, P
机构
来源
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS | 1993年 / 89卷 / 14期
关键词
D O I
10.1039/ft9938902433
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Using calorimetric and IR spectroscopic methods, the values of thermodynamic functions of (1 : 1) hydrogen-bond complex formation between cholesterol and some proton acceptors in CCl4 have been determined. The self-association of cholesterol in the solvent used was taken into account in calculations. The proton acceptors used are oxygen bases containing C-0, -O-, P-0 and S-0 groups. The values of DELTA(f)H were compared with those previously obtained for the pure bases. The enthalpy of hydrogen-bond complex formation of cholesterol is a linear function of Gutmann's donor number for all the proton acceptor compounds examined. Badger-Bauer' s relation {DELTA(f)H = f[DELTAnu(OH)]} is not satisfied as well as DELTA(f)H = f(DN) but it allows the prediction of values of enthalpy of complex formation between cholesterol and proton acceptors within +/- 1.5 kJ mol-1 limits.
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页码:2433 / 2435
页数:3
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