PRIOR MEDICAL CONDITIONS AND THE RISK OF ADULT LEUKEMIA IN SHANGHAI, PEOPLES-REPUBLIC-OF-CHINA

被引：147

作者：

ZHENG, W

LINET, MS

SHU, XO

PAN, RP

GAO, YT

FRAUMENI, JF

机构：

[1] Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD

[2] Department of Epidemiology, Shanghai Cancer Institute

[3] Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD

[4] Department of Hematology, Renji Hospital, Shanghai Second Medical University

来源：

CANCER CAUSES & CONTROL | 1993年 / 4卷 / 04期

关键词：

APPENDECTOMY; DISEASES; LEUKEMIA; PEOPLES-REPUBLIC-OF-CHINA; RADIATION; RISK FACTORS; TUBERCULOSIS;

D O I：

10.1007/BF00051339

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A population-based case-control interview study of 486 adult leukemia cases and 502 healthy controls was carried out in Shanghai, People's Republic of China during 1987-89 to evaluate the etiologic role of prior medical conditions, medications, and diagnostic X-rays. Risks were examined separately for 236 cases with acute non-lymphocytic leukemia (ANLL), 79 with chronic myeloid leukemia (CML), 81 with acute lymphocytic leukemia (ALL), and 21 with chronic lymphocytic leukemia (CLL). Little difference was found between cases and controls for prior history of diabetes, hypertension, allergic conditions, most medications, and diagnostic X-rays. A few significant associations were observed for appendectomy, tuberculosis, and for several other chronic disorders with specific leukemia cell types, but the odds ratio estimates for most of these ranged from two to three and, with the exception of the two specified above, were based generally on five or fewer exposed controls. In contrast to an association with childhood leukemia in Shanghai, prior use of chloramphenicol was not linked with ANLL or other forms of adult leukemia. Further research is needed to clarify the relation of specific medical conditions and exposures with particular subtypes of leukemia, and to examine reasons for the low incidence of CLL in China and other Asian populations.

引用

页码：361 / 368

页数：8

共 39 条

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