DEPRESSED IMMUNE SURVEILLANCE AGAINST CANCER - ROLE OF DEFICIENT T-CELL - EXTRACELLULAR-MATRIX INTERACTIONS

被引:19
作者
GORSKI, A
CASTRONOVO, V
STEPIENSOPNIEWSKA, B
GRIEB, P
RYBA, M
MROWIEC, T
KORCZAKKOWALSKA, G
WIERZBICKI, P
MATYSIAK, W
DYBOWSKA, B
PIEKARCZYK, J
GAWALKIEWICZ, J
KRYST, P
BORKOWSKI, A
TOLLOCZKO, T
机构
[1] UNIV LIEGE,LIEGE,BELGIUM
[2] POLISH ACAD SCI,WARSAW,POLAND
关键词
CANCER; EXTRACELLULAR MATRIX; ADHESION; CO-STIMULATION; T CELLS; COLLAGEN IV; FIBRONECTIN;
D O I
10.3109/15419069409004441
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell : ECM interactions.
引用
收藏
页码:225 / 233
页数:9
相关论文
共 17 条
[1]  
APPLEGATE KG, 1990, CANCER RES, V50, P7153
[2]  
GARBE C, 1993, J INVEST DERMATOL, V100, P239
[3]   ABNORMAL T-CELL COSTIMULATION BY PROTEINS OF THE EXTRACELLULAR-MATRIX IN HUMAN RENAL ALLOGRAFTING [J].
GORSKI, A ;
MROWIEC, T ;
PACZEK, L ;
STEPIENSOPNIEWSKA, B .
RESEARCH IN IMMUNOLOGY, 1993, 144 (05) :305-309
[4]   ABNORMALITIES IN T-CELL INTERACTIONS WITH THE EXTRACELLULAR-MATRIX PROTEINS IN A PATIENT WITH WEGENERS GRANULOMATOSIS [J].
GORSKI, A ;
PIEKARCZYK, J ;
SKURZAK, H ;
NOWACZYK, M ;
DYBOWSKA, B ;
STEPIENSOPNIEWSKA, B ;
KORCZAKKOWALSKA, G ;
PAZDUR, J ;
FILIPOWICZSOSNOWSKA, A .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1993, 69 (02) :149-154
[5]  
HERSHKOVIZ R, 1993, IMMUNOLOGY, V78, P50
[6]   LEUKOCYTE INTEGRIN ACTIVATION [J].
HOGG, N ;
BENNETT, R ;
CABANAS, C ;
DRANSFIELD, I .
KIDNEY INTERNATIONAL, 1992, 41 (03) :613-616
[7]   INTEGRINS - VERSATILITY, MODULATION, AND SIGNALING IN CELL-ADHESION [J].
HYNES, RO .
CELL, 1992, 69 (01) :11-25
[8]   T-CELL RECOGNITION OF HUMAN TUMORS - IMPLICATIONS FOR MOLECULAR IMMUNOTHERAPY OF CANCER [J].
IOANNIDES, CG ;
WHITESIDE, TL .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1993, 66 (02) :91-106
[9]   ACTIVATION AND ADHESION MOLECULE EXPRESSION ON LYMPHOID INFILTRATES IN HUMAN GLIOBLASTOMAS [J].
KUPPNER, MC ;
HAMOU, MF ;
DETRIBOLET, N .
JOURNAL OF NEUROIMMUNOLOGY, 1990, 29 (1-3) :229-238
[10]  
MIESCHER S, 1986, J IMMUNOL, V136, P1899