1ST-PASS EFFECT AFTER RECTAL ADMINISTRATION OF THIAZINAMIUM METHYLSULFATE

被引：13

作者：

JONKMAN, JHG

VANBORK, LE

WIJSBEEK, J

BOLHUISDEVRIES, AS

ZEEUW, RAD

ORIE, NGM

COX, HLM

机构：

[1] LAB DUTCH PHARMACISTS,HAGUE,NETHERLANDS

[2] STATE UNIV GRONINGEN,DEPT INTERNAL MED,DIV PULM,GRONINGEN,NETHERLANDS

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Absorption; rectal—thiazinamium methylsulfate in humans; Antihistaminics—thiazinamium methylsulfate; rectal absorption and metabolism in humans; Metabolism—thiazinamium methylsulfate in humans; Phenothiazine derivatives—thiazinamium methylsulfate; Thiazinamium methylsulfate—rectal absorption and metabolism in humans;

D O I：

10.1002/jps.2600680121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The absorption and metabolism of the quaternary ammonium compound thiazinamium methylsulfate were studied in humans using plasma concentration data and urinary excretion measurements. After giving a dose of 150 mg in suppositories, the relative bioavailability was 5.8 ± 3.2 (SD) % of the dose, comparable to the values obtained following oral administration. The degree of first‐pass effect observed after rectal administration was comparable with that after oral administration. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：69 / 72

页数：4

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