HTLV-I/II SEROPOSITIVITY AND DEATH FROM AIDS AMONG HIV-1 SEROPOSITIVE INTRAVENOUS-DRUG-USERS

被引:119
作者
PAGE, JB [1 ]
LAI, SH [1 ]
CHITWOOD, DD [1 ]
KLIMAS, NG [1 ]
SMITH, PC [1 ]
FLETCHER, MA [1 ]
机构
[1] UNIV MIAMI,SCH MED,MIAMI,FL 33152
关键词
D O I
10.1016/0140-6736(90)91456-K
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In a prospective study of street-recruited intravenous drug users (IVDUs) in Miami, Florida, USA, 107 (46·5%) of 230 IVDUs were infected with HIV-1. Of these HIV-1 seropositive individuals, 23 were also infected with human T-lymphotropic virus type I or II (HTLV-I/II). To test the hypothesis that HTLV-I/II infection has an effect on the survival of HIV-1 seropositive IVDUs, various baseline clinical and laboratory HIV-1 related indices in HTLV-I/II positive and negative groups were compared. Life table analysis and Cox's proportional hazards model were used to estimate the potential effect of HTLV-I/II infection on the survival patterns of people infected with HIV-1. IVDUs infected with both viruses were three times more likely to die from AIDS during follow-up than were those infected with HIV-1 only. This finding suggests that HTLV-I/II seropositivity may adversely affect the clinical outcome of HIV-1 seropositive patients. © 1990.
引用
收藏
页码:1439 / 1441
页数:3
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