CLONING AND SEQUENCE-ANALYSIS OF A HUMAN TYPE-A-B HNRNP PROTEIN

被引：44

作者：

KHAN, FA

JAISWAL, AK

SZER, W

机构：

[1] NYU,SCH MED,DEPT BIOCHEM,550 1ST AVE,NEW YORK,NY 10016

[2] NYU,SCH MED,DEPT CELL BIOL,NEW YORK,NY 10016

来源：

FEBS LETTERS | 1991年 / 290卷 / 1-2期

关键词：

HNRNP PROTEIN; RNA BINDING MOTIF; DOMAIN STRUCTURE;

D O I：

10.1016/0014-5793(91)81249-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AcDNA encoding a 284 residue long type A/B hn RNP protein has been cloned. This protein, previously referred to as type C [(1987) J. Biol. Chem. 262, 17126-17137], is an RNA unwinding protein from HeLa 40S hnRNP with a high affinity for G- followed by U-rich sequences. The N-terminal part of the protein contains two consensus RNA binding domains present in a number of other RNA binding proteins. The C-terminal part is glycine-rich and contains a potential ATP/GTP binding loop. The distribution of charged amino acids is highly uneven and there are multiple potential phosphorylation sites.

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页码：159 / 161

页数：3

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