ENHANCED PRODUCTION OF INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA BY CULTURED PERIPHERAL-BLOOD MONOCYTES FROM PATIENTS WITH SCLERODERMA

被引：49

作者：

UMEHARA, H

KUMAGAI, S

MURAKAMI, M

SUGINOSHITA, T

TANAKA, K

HASHIDA, S

ISHIKAWA, E

IMURA, H

机构：

[1] KYOTO UNIV HOSP,SCH MED,DEPT INTERNAL MED 2,SAKYO KU,KYOTO 606,JAPAN

[2] UTANO NATL HOSP,DEPT MED,KYOTO,JAPAN

[3] MED COLL MIYAZAKI,DEPT BIOCHEM,MIYAZAKI,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 06期

关键词：

D O I：

10.1002/art.1780330619

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cultured peripheral blood mononuclear cells from 20 patients with scleroderma were shown to produce high levels of interleukin‐1α, interleukin‐1β, and tumor necrosis factor α. There were positive correlations between the production of these 3 molecules. Purified monocytes from these patients produced much more tumor necrosis factor α than did those from normal subjects, even without lipopolysaccharide stimulation. These results show the hyperactivity of monocytes from scleroderma patients. Copyright © 1990 American College of Rheumatology

引用

页码：893 / 897

页数：5

共 13 条

[1]

ALCOCERVARELA J, 1985, CLIN EXP IMMUNOL, V59, P666

[2] STIMULATION OF THE HYALURONIC-ACID LEVELS OF HUMAN SYNOVIAL FIBROBLASTS BY RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA, TUMOR NECROSIS FACTOR-BETA (LYMPHOTOXIN), INTERLEUKIN-1-ALPHA, AND INTERLEUKIN-1-BETA [J].