CONSERVED CYSTEINE RESIDUES IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSMEMBRANE ENVELOPE PROTEIN ARE ESSENTIAL FOR PRECURSOR ENVELOPE CLEAVAGE

被引：43

作者：

DEDERA, D

GU, RL

RATNER, L

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 02期

关键词：

D O I：

10.1128/JVI.66.2.1207-1209.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The transmembrane (TM) protein of human immunodeficiency virus type 1 has been demonstrated to be involved in viral infectivity and syncytium formation. Two highly conserved cysteine residues in the extracellular region of the TM protein are shown to be essential for processing the 160-kDa envelope precursor into the active 120- and 41-kDa mature forms.

引用

页码：1207 / 1209

页数：3

共 18 条

[1] HIV CAUSES AIDS
BLATTNER, W
GALLO, RC
TEMIN, HM
[J]. SCIENCE, 1988, 241 (4865) : 515 - 515
[2] IDENTIFICATION OF THE FUSION PEPTIDE OF PRIMATE IMMUNODEFICIENCY VIRUSES
BOSCH, ML
EARL, PL
FARGNOLI, K
PICCIAFUOCO, S
GIOMBINI, F
WONGSTAAL, F
FRANCHINI, G
[J]. SCIENCE, 1989, 244 (4905) : 694 - 697
[3] BRACIALE T, COMMUNICATION
[4] ATTENUATION OF HIV-1 INFECTIVITY BY AN INHIBITOR OF OLIGOSACCHARIDE PROCESSING
DEDERA, D
VANDERHEYDEN, N
RATNER, L
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (06) : 785 - 794
[5] OLIGOMERIC STRUCTURE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN
EARL, PL
DOMS, RW
MOSS, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 648 - 652
[6] CHARACTERIZATION OF THE FUSION DOMAIN OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN GP41
FREED, EO
MYERS, DJ
RISSER, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) : 4650 - 4654
[7] A GENERAL-MODEL FOR THE TRANSMEMBRANE PROTEINS OF HIV AND OTHER RETROVIRUSES
GALLAHER, WR
BALL, JM
GARRY, RF
GRIFFIN, MC
MONTELARO, RC
[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1989, 5 (04) : 431 - 440
[8] HARLOW E, 1988, ANTIBODIES LAB MANUA, P335
[9] COMPLETE SEQUENCE OF THE ROUS-SARCOMA VIRUS ENV GENE - IDENTIFICATION OF STRUCTURAL AND FUNCTIONAL REGIONS OF ITS PRODUCT
HUNTER, E
HILL, E
HARDWICK, M
BHOWN, A
SCHWARTZ, DE
TIZARD, R
[J]. JOURNAL OF VIROLOGY, 1983, 46 (03) : 920 - 936
[10] FUNCTIONAL REGIONS OF THE ENVELOPE GLYCOPROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
KOWALSKI, M
POTZ, J
BASIRIPOUR, L
DORFMAN, T
WEI, CG
TERWILLIGER, E
DAYTON, A
ROSEN, C
HASELTINE, W
SODROSKI, J
[J]. SCIENCE, 1987, 237 (4820) : 1351 - 1355

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