T-CELL GROWTH-FACTORS AND THE TREATMENT OF PATIENTS WITH CANCER

被引:19
作者
LOTZE, MT
机构
[1] UNIV PITTSBURGH,DEPT MOLEC GENET,PITTSBURGH,PA 15260
[2] UNIV PITTSBURGH,DEPT BIOCHEM,PITTSBURGH,PA 15260
[3] PITTSBURGH CANC INST,SURG ONCOL SECT,PITTSBURGH,PA 15261
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 62卷 / 01期
关键词
D O I
10.1016/0090-1229(92)90040-U
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T-cell maturation has traditionally been felt to occur primarily within the thymus but it is now clear that dynamic processes in the periphery govern many functions such as T-cell activation, proliferation, tolerization, and migration into peripheral tissues. Four T-cell growth factors have now been identified. These include: interleukin-2 (IL-2), IL-4, IL-7, and a potent cofactor recently described, IL-10. These factors are believed to work synergistically in the fine regulation of the lymphoid pool. Both IL-2 and IL-4 have entered clinical trials with significant responses in the IL-2-based regimens of up to 40 to 50% in certain tumors. IL-7 and IL-10 are in preclinical studies. Although IL-2, IL-4, and IL-7 have been shown to induce lymphokine-activated killer cell activity from sensitive precursors, such studies have yet to be performed with IL-10. © 1992.
引用
收藏
页码:S47 / S54
页数:8
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