HIGHLY STEREOSELECTIVE ASYMMETRIC HYDROGENATION OF 2-BENZAMIDOMETHYL-3-OXOBUTANOATE CATALYZED BY CATIONIC BINAP RUTHENIUM(II) COMPLEXES

被引：82

作者：

MASHIMA, K

MATSUMURA, Y

KUSANO, K

KUMOBAYASHI, H

SAYO, N

HORI, Y

ISHIZAKI, T

AKUTAGAWA, S

TAKAYA, H

机构：

[1] TAKASAGO RES INST INC,KAMATA,OHTA KU,TOKYO 144,JAPAN

[2] KYOTO UNIV,FAC ENGN,DEPT IND CHEM,SAKYO KU,KYOTO 606,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 09期

关键词：

D O I：

10.1039/c39910000609

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate has been accomplished by using [Rul{(R)-binap}(p-cymene)]l and corresponding complexes of derivatives of binap as catalyst, giving methyl (2S,3R)-2-benzamidomethyl-3-hydroxybutanoate, a versatile intermediate for the synthesis of beta-lactam antibiotics, in up to 98% diastereoisomeric excess and 99% enantiomeric excess.

引用

页码：609 / 610

页数：2

共 10 条

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