SYNTHESIS OF 5-[(METHYLTHIO)METHYL]-2'-DEOXYURIDINE, THE CORRESPONDING SULFOXIDE AND SULFONE, AND THEIR 5'-PHOSPHATES - ANTI-VIRAL EFFECTS AND THYMIDYLATE SYNTHETASE INHIBITION

被引：16

作者：

SCHMIDT, CL

CHANG, CTC

DECLERCQ, E

DESCAMPS, J

MERTES, MP

机构：

[1] UNIV KANSAS,DEPT MED CHEM,LAWRENCE,KS 66045

[2] CATHOLIC UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 03期

关键词：

D O I：

10.1021/jm00177a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：252 / 256

页数：5

共 17 条

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ROHM, E .

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[2] 5(ALPHA-BROMOACETYL)-2'-DEOXYURIDINE 5'-PHOSPHATE - MECHANISM BASED AFFINITY LABEL FOR THYMIDYLATE SYNTHETASE [J].

BROUILLETTE, CB ;

CHANG, CTC ;

MERTES, MP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 87 (02) :613-618

[3] 5-(ALPHA-BROMOACETYL)-2'-DEOXYURIDINE 5'-PHOSPHATE - AFFINITY LABEL FOR THYMIDYLATE SYNTHETASE [J].

BROUILLETTE, CB ;

CHANG, CTC ;

MERTES, MP .

JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (12) :1541-1544

[4]

CRUSBERG TC, 1970, J BIOL CHEM, V245, P5292

[5]

DARON HH, 1978, J BIOL CHEM, V253, P940

[6]

DECLERCQ E, 1978, MOL PHARMACOL, V14, P422

[7]

DECLERCQ E, 1979, P NATL ACAD SCI USA, V76, P2947, DOI 10.1073/pnas.76.6.2947

[8]

DECLERCQ E, 1978, J CARB-NUCLEOS-NUCL, V5, P187

[9] ANTI-VIRAL ACTIVITY OF 5-METHYLTHIOMETHYL-2'-DEOXYURIDINE AND OTHER 5-SUBSTITUTED 2'-DEOXYURIDINES [J].

DECLERCQ, E ;

DESCAMPS, J ;

SCHMIDT, CL ;

MERTES, MP .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (22) :3249-3254

[10]

DECLERCQ E, 1979, ANTIMETABOLITES BIOC, P275

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