DESIGN AND SYNTHESIS OF CHIRAL STATIONARY PHASE DERIVED FROM (S)-[10]PARACYCLOPHANE-13-CARBOXYLIC ACID FOR THE HPLC SEPARATION OF ENANTIOMERS

被引：17

作者：

OI, S ^{[1
]}

MIYANO, S ^{[1
]}

机构：

[1] TOHOKU UNIV, FAC ENGN, DEPT BIOCHEM & ENGN, AOBA KU, SENDAI, MIYAGI 980, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 06期

关键词：

D O I：

10.1246/cl.1992.987

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Homochiral (S)-[10]paracyclophane-13-carboxylic acid ((S)-1) could conveniently be obtained on a preparative scale via fractional crystallization of the (S)-1-phenylethylamide diastereomers. (S)-1 was used for the first time as a stereodifferentiating element with planar chirality for a new chiral stationary phase (CSP) for HPLC. The CSP, which was prepared by bonding (S)-1 to gamma-aminopropylsilanized silica gel via amide linkage, recognized a wide range of enantiomers by HPLC.

引用

页码：987 / 990

页数：4

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