HUMAN EBV-TRANSFORMED LYMPHOCYTES OF PATIENTS WITH SCHISTOSOMA-JAPONICUM INFECTION SECRETE IDIOTYPICALLY RELATED IMMUNOREGULATORY ANTIBODIES

被引：7

作者：

KRESINA, TF ^{[1
]}

CHEEVER, LW ^{[1
]}

CHIREAU, M ^{[1
]}

JOHNSON, J ^{[1
]}

RAMIREZ, B ^{[1
]}

PETERS, P ^{[1
]}

OLDS, GR ^{[1
]}

机构：

[1] RES INST TROP MED,DEPT IMMUNOL,MANILA,PHILIPPINES

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1992年 / 65卷 / 03期

关键词：

D O I：

10.1016/0090-1229(92)90164-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes derived from the peripheral blood of individuals infected with Schistosoma japonica were transformed in vitro with Ebstein-Barr virus (EBV). Serological characterization of antibody molecules revealed both antigen reactive (idiotypic) and anti-idiotypic transformants. One idiotypic EBV transformant, LO2C2, describes a major cross-reactive idiotype associated with anti-antigen binding molecules. Other antibody populations expressing idiotypic cross-reactivity were derived from separate individuals showing shared idiotypy in S. japonicum field study populations in the Republic of Philippines. Both idiotypic and anti-idiotypic molecules suppressed parasite antigen-driven blastogenesis of heterologous human peripheral blood lymphocytes. The data show a serologically related immunoregulatory immune network in patients in the Republic of the Philippines which is serologically distinct from idiotypy expressed in other selected S. japonicum endemic areas in the Far East. © 1992.

引用

页码：325 / 329

页数：5

共 15 条

[1] DELAYED HYPERSENSITIVITY-TYPE GRANULOMA FORMATION AND DERMAL REACTION INDUCED AND ELICITED BY A SOLUBLE FACTOR ISOLATED FROM SCHISTOSOMA MANSONI EGGS
BOROS, DL
WARREN, KS
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 132 (03) : 488 - +
[2] GARB KS, 1982, J IMMUNOL, V129, P2752
[3] HERYLN D, 1987, P NATL ACAD SCI USA, V84, P8055
[4] Kresina T F, 1991, Hum Antibodies Hybridomas, V2, P42
[5] CONCOMITANT CELLULAR AND HUMORAL EXPRESSION OF A REGULATORY CROSS-REACTIVE IDIOTYPE IN ACUTE SCHISTOSOMA-JAPONICUM INFECTION
KRESINA, TF
OLDS, GR
[J]. INFECTION AND IMMUNITY, 1986, 53 (01) : 90 - 94
[6] COMPARISON OF IMMUNE REPERTOIRES OF CHINESE AND PHILIPPINE PATIENTS INFECTED WITH SCHISTOSOMA-JAPONICUM
KRESINA, TF
GUAN, XH
POSNER, M
RAMIREZ, B
OLDS, GR
[J]. INFECTION AND IMMUNITY, 1991, 59 (12) : 4698 - 4700
[7] OLDS GR, 1982, J IMMUNOL, V128, P1391
[8] NETWORK INTERACTIONS IN SCHISTOSOMA-JAPONICUM INFECTION - IDENTIFICATION AND CHARACTERIZATION OF A SEROLOGICALLY DISTINCT IMMUNOREGULATORY AUTO-ANTIIDIOTYPIC ANTIBODY POPULATION
OLDS, GR
KRESINA, TF
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (06) : 2338 - 2347
[9] OLVEDA R, 1988, CLIN RES, V36, pA622
[10] PARRA JC, 1988, J IMMUNOL, V140, P2401

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