INVOLVEMENT OF M1 MUSCARINIC RECEPTORS IN THE INITIATION OF CHOLINERGICALLY INDUCED EPILEPTIC SEIZURES IN THE RAT-BRAIN

被引:46
作者
CRUICKSHANK, JW
BRUDZYNSKI, SM
MCLACHLAN, RS
机构
[1] UNIV WESTERN ONTARIO HOSP,DEPT CLIN NEUROL SCI,LONDON N6A 5A5,ON,CANADA
[2] UNIV WESTERN ONTARIO HOSP,EPILEPSY RES LAB,LONDON N6A 5A5,ON,CANADA
基金
英国医学研究理事会;
关键词
EXPERIMENTAL EPILEPSY; GENERALIZED SEIZURE; CHOLINERGIC SYSTEM; MUSCARINIC RECEPTOR; M1; RECEPTOR; CARBACHOL; PIRENZEPINE; MECAMYLAMINE; INTRACEREBRAL INJECTION; ZONA INCERTA; RAT;
D O I
10.1016/0006-8993(94)90017-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 mu g) produced generalized seizures in 12 of 20 rats studied. Local pretreatment with equimolar doses of acetylcholine receptor antagonists was used as a method of determining the receptor type involved in the initiation of cholinergically induced seizures in the rat diencephalon. Pretreatment with the M1 muscarinic receptor antagonist, pirenzepine (7 mu g), abolished carbachol-induced seizures in 91% of the animals tested. The M2 muscarinic receptor antagonist, methoctramine (12 mu g) and the nicotinic receptor antagonist, mecamylamine (3 mu g), were relatively ineffective in antagonizing seizures in 9% and 27%, respectively. The results suggest that M1 muscarinic receptors are preferentially involved in the initiation of generalized epileptic seizures in the basal diencephalon of the rat.
引用
收藏
页码:125 / 129
页数:5
相关论文
共 37 条
[1]   PHARMACOLOGY OF GROSS BEHAVIORAL-EFFECTS OF CHOLINOMIMETIC SUBSTANCES INJECTED INTO CEREBRAL-VENTRICLES OF UNANESTHETIZED CATS - EVIDENCE FOR CENTRAL MUSCARINIC MEDIATION [J].
BELESLIN, DB ;
GRBOVIC, L ;
RADMANOVIC, BZ .
NEUROPHARMACOLOGY, 1974, 13 (12) :1163-1169
[3]   FAILURE OF AUTONOMIC AND CENTRAL NERVOUS-SYSTEM BLOCKING-AGENTS TO ANTAGONIZE GROSS BEHAVIORAL-EFFECTS OF TUBOCURARINE INJECTED INTRAVENTRICULARLY IN CONSCIOUS CATS [J].
BELESLIN, DB ;
SAMARDZIC, R .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1976, 28 (06) :519-519
[4]  
BHATTACHARYA SK, 1991, INDIAN J EXP BIOL, V29, P237
[5]   CHOLINERGICALLY MEDIATED REDUCTION OF LOCOMOTOR-ACTIVITY FROM THE BASAL FOREBRAIN OF THE RAT [J].
BRUDZYNSKI, SM ;
MCLACHLAN, RS ;
GIRVIN, JP .
EXPERIMENTAL NEUROLOGY, 1989, 105 (02) :197-205
[6]   AN EEG ANALYSIS OF CONVULSIVE ACTIVITY PRODUCED BY CHOLINERGIC AGENTS [J].
COHEN, SL ;
MORLEY, BJ ;
SNEAD, OC .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY, 1981, 5 (04) :383-388
[7]  
CRUICKSHANK J W, 1991, Society for Neuroscience Abstracts, V17, P1607
[8]  
Decsi L., 1969, RECENT DEV NEUROBIOL, V2, P182
[9]   BRAIN-STEM EXPERIMENTAL SEIZURES PRODUCED BY MICROINJECTIONS OF CARBACHOL [J].
ELAZAR, Z ;
FELDMAN, Z .
EPILEPSIA, 1987, 28 (05) :463-470
[10]  
FELDBERG W, 1962, J PHYSIOL-LONDON, V160, P258, DOI 10.1113/jphysiol.1962.sp006845