ULTRASOUND-MEDIATED TRANSDERMAL PROTEIN DELIVERY

被引：626

作者：

MITRAGOTRI, S ^{[1
]}

BLANKSCHTEIN, D ^{[1
]}

LANGER, R ^{[1
]}

机构：

[1] MIT, DEPT CHEM ENGN, CAMBRIDGE, MA 02139 USA

来源：

SCIENCE | 1995年 / 269卷 / 5225期

关键词：

D O I：

10.1126/science.7638603

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transdermal drug delivery offers a potential method of drug administration. However, its application has been limited to a few low molecular weight compounds because of the extremely low permeability of human skin. Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible. It was possible to deliver and control therapeutic doses of proteins such as insulin, interferon gamma, and erythropoeitin across human skin. Low-frequency ultrasound is thus a potential noninvasive substitute for traditional methods of drug delivery, such as injections.

引用

页码：850 / 853

页数：4

共 25 条

[1] POSSIBILITY OF MICROCAVITATION FROM DIAGNOSTIC ULTRASOUND [J].