5,5-DIARYLPENTA-2,4-DIENOIC ACID AMIDES AS POTENTIAL ANTIMALARIAL AGENTS

被引：7

作者：

COLWELL, WT

LANGE, JH

HENRY, DW

机构：

[1] Department of Pharmaceutical Chemistry, Stanford Research Institute, Menlo Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 04期

关键词：

D O I：

10.1021/jm00310a604

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5,5-diarylpenta-2,4-dienoic acids and their amides have been synthesized and evaluated as antimalarial agents. The acids were prepared from the corresponding diaryl ketones either directly by a Reformatsky procedure or through acetylenic alcohol and acrolein intermediates. The preparation of a series of 3,3-bis(4-chlorophenyl)acrylic acid amides is also reported. One compound, N,N-diethyl-5,5-bis(4-chlorophenyl)-penta-2,4-dienoic acid amide, provided significant antiplasmodial activity. © 1968, American Chemical Society. All rights reserved.

引用

页码：749 / &

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