BICYCLIC HETEROCYCLES WITH NITROGEN AT THE RING JUNCTION 1 - SYNTHESIS AND CHEMISTRY OF IMIDAZO[5,1-F]-1,2,4-TRIAZINES

被引：13

作者：

CLARKE, RW ^{[1
]}

GARSIDE, SC ^{[1
]}

LUNTS, LHC ^{[1
]}

HARTLEY, D ^{[1
]}

HORNBY, R ^{[1
]}

OXFORD, AW ^{[1
]}

机构：

[1] ALLEN & HANBURYS RES LTD,WARE SG12 0DJ,HERTFORDSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 04期

关键词：

D O I：

10.1039/p19790001120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the potential bronchodilators 2-amino-5-methyl-7- propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (12) and the corresponding triazine (2) is described and some chemical reactions of this novel ring system are discussed. Although X-ray analysis of the methanesulphonate salt of (12) indicated that protonation occurred on the nitrogen atom at position 6, acylation of the primary amino-group could still be achieved using a carboxylic acid in the presence of methanesulphonyl chloride.

引用

页码：1120 / 1124

页数：5

共 10 条

[1]

ALBERT A, 1962, IONIZATION CONSTANTS, P69

[2] ARYLOXYALKYLAMINOGUANIDINES . THEIR SYNTHESIS AND BIOLOGICAL PROPERTIES [J].

AUGSTEIN, J ;

GREEN, SM ;

MONRO, AM ;

WRIGLEY, TI ;

KATRITZK.AR ;

TIDDY, GJT .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (03) :391-&

[3] NEW INHIBITOR OF PHOSPHODIESTERASE WITH ANTI-BRONCHOCONSTRICTOR PROPERTIES [J].

DAVIES, GE ;

ROSE, FL ;

SOMERVILLE, AR .

NATURE-NEW BIOLOGY, 1971, 234 (45) :50-+

[4] REACTION PATTERNS OF 2,7-DIAMINO-4,5-DIMETHYL-IMIDAZO[5,1-F]-AS-TRIAZINE [J].

KREUTZBE.A ;

SCHUCKER, R .

ARCHIV DER PHARMAZIE, 1973, 306 (10) :730-736

[5] PARENT COMPOUND OF 2,7-DIAMINO-IMIDAZO 5,1-F-AS-TRIAZINES DEVOID OF ALKYL-GROUPS [J].

KREUTZBERGER, A ;

SCHUCKER, R .

ARCHIV DER PHARMAZIE, 1973, 306 (11) :801-807

[6]

KREUTZBERGER A, 1973, ARCH PHARM, V306, P561

[7]

KREUTZBERGER A, 1973, ARCH PHARM, V306, P697

[8] CONDENSATIONS WITH HYDRAZINE-N,N' - DICARBOYLIC ACID DIAMIDINE .17. 4,5-DIALKYL DERIVATIVES OF 2,7-DIAMINOIMIDAZO(5,1-F)-AS-TRIAZINE [J].

KREUTZBERGER, A ;

SCHUCKER, R .

TETRAHEDRON, 1973, 29 (10) :1413-1417

[9] HEXAHYDRO-BENZO[E]-AS-TRIAZINES [J].

KREUTZBERGER, A ;

SCHUCKER, R .

ARCHIV DER PHARMAZIE, 1974, 307 (02) :95-99

[10] S-TRIAZOLOPYRIMIDINES .1. SYNTHESIS AS POTENTIAL THERAPEUTIC AGENTS [J].

MILLER, GW ;

ROSE, FL .

JOURNAL OF THE CHEMICAL SOCIETY, 1963, (DEC) :5642-&

← 1 →