NONRACEMIZING SYNTHESIS AND STEREOSELECTIVE REDUCTION OF CHIRAL ALPHA-AMINO KETONES

被引：78

作者：

REETZ, MT

DREWES, MW

LENNICK, K

SCHMITZ, A

HOLDGRUN, X

机构：

[1] Fachbereich Chemie der Universitaet, 3550 Marburg, Hans-Meerwein-Str

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 06期

关键词：

D O I：

10.1016/0957-4166(90)90037-B

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

α-Amino acids can be doubly benzylated at nitrogen, forming N,N-dibenzyl amino acids which can be converted into α-amino ketones 4 without appreciable racemization. The latter undergo stereoselective reduction with NaBH4 under non-chelation control to form amino alkohols 5. © 1990.

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页码：375 / 378

页数：4

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