DELETION OF 55 OPEN READING FRAMES FROM THE TERMINI OF VACCINIA VIRUS

被引：101

作者：

PERKUS, ME ^{[1
]}

GOEBEL, SJ ^{[1
]}

DAVIS, SW ^{[1
]}

JOHNSON, GP ^{[1
]}

NORTON, EK ^{[1
]}

PAOLETTI, E ^{[1
]}

机构：

[1] VIROGENET CORP,465 JORDAN RD,RENSSELAER TECHNOL PK,TROY,NY 12180

来源：

VIROLOGY | 1991年 / 180卷 / 01期

关键词：

D O I：

10.1016/0042-6822(91)90047-F

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Each copy of the inverted terminal repeat of vaccinia virus consists of 8 kb of DNA containing 9 ORFS flanked near the terminus of the genome by 4 kb of repetitive DNA which in turn contains blocks of tandem repeats. Using plasmids containing repetitive DNA as the external arm, we have generated deletions at both the left and the right termini of the vaccinia genome. We report here the engineered deletion within a single vaccinia virus of 32.7 kb of DNA (including 38 ORFS) from the left terminus and 14.9 kb of DNA (including 17 ORFS) from the right terminus. © 1991.

引用

页码：406 / 410

页数：5

共 26 条

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