DIRECT RESOLUTION OF SOME PHENYLGLYCINES BY LIQUID-CHROMATOGRAPHY ON A CHIRAL CROWN-ETHER PHASE

被引：24

作者：

UDVARHELYI, PM

WATKINS, JC

机构：

[1] Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol

来源：

CHIRALITY | 1990年 / 2卷 / 03期

关键词：

chiral crown ether‐type phases; chiral stationary phases; enantiomeric separations; guest–host complexation; phenylglycines;

D O I：

10.1002/chir.530020313

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The optical resolution of a series of 12 amino acids of the phenylglycine family was studied using a chiral crown ether column. The effects of pH, temperature, and mobile phase additive were investigated. In three examples it was confirmed that the R enantiomer eluted prior to the S enantiomer. Most phenylglycines were resolved with large separation factors; those with two functional groups substituents on opposing sides of the phenyl ring, however, were not well separated. Copyright © 1990 Wiley‐Liss, Inc.

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页码：200 / 204

页数：5

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