PURIFICATION OF ACHATIN-I FROM THE ATRIA OF THE AFRICAN GIANT SNAIL, ACHATINA FULICA, AND ITS POSSIBLE FUNCTION

被引：45

作者：

FUJIMOTO, K

KUBOTA, I

YASUDAKAMATANI, Y

MINAKATA, H

NOMOTO, K

YOSHIDA, M

HARADA, A

MUNEOKA, Y

KOBAYASHI, M

机构：

[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & SCI,PHYSIOL LAB,HIROSHIMA 730,JAPAN

[2] SUNTORY BIOPHARMA TECH CTR,GUMMA 37005,JAPAN

[3] SUNTORY INST BIOORGAN RES,SHIMAMOTO,OSAKA 618,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91867-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Achatin-I previously purified from the ganglia of the African giant snail Achatina fulica was isolated from the atria of this snail. Achatin-I appeared to enhance the cardiac activity in two ways; centrally this peptide increased impulse frequency and produced spike broadening of the identified heart excitatory neuron, PON, and peripherally it enhanced amplitude and frequency of the heart beat. Achatin-I showed excitatory actions not only on the heart but on several other muscles. © 1991.

引用

页码：847 / 853

页数：7

共 9 条

[1] DELTORPHINS - A FAMILY OF NATURALLY-OCCURRING PEPTIDES WITH HIGH-AFFINITY AND SELECTIVITY FOR DELTA-OPIOID BINDING-SITES [J].