HUMAN RECOMBINANT LYMPHOKINES AND CYTOKINES INDUCE PULMONARY EOSINOPHILIA IN THE GUINEA-PIG WHICH IS INHIBITED BY KETOTIFEN AND AH-21-132

被引：37

作者：

KINGS, MA ^{[1
]}

CHAPMAN, I ^{[1
]}

KRISTERSSON, A ^{[1
]}

SANJAR, S ^{[1
]}

MORLEY, J ^{[1
]}

机构：

[1] SANDOZ LTD, DIV PHARMA, CH-4002 BASEL, SWITZERLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 91卷 / 04期

关键词：

D O I：

10.1159/000235141

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Subcutaneous or intraperitoneal injection of recombinant human granulocyte-macrophage/col-ony-stimulating factor, interleukin 3, or mouse tumour necrosis factor alpha, but not recombinant human interferon gamma, platelet-derived growth factor, or transforming growth factor beta caused selective eosinophilia of the pulmonary airways in the guinea pig. Unlike responses to platelet-activating factor, there was no attendant detectable airway hyperreactivity, but in common with responses to platelet-activating factor, eosinophilia of the airways was prevented by pretreatment with ketotifen or AH 21-132. Cytokines or lymphokines may contribute to pulmonary eosinophilia in diseases such as asthma. © 1990 S. Karger AG, Basel.

引用

页码：354 / 361

页数：8

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