LUNG DEPOSITION OF A NACYSTELYN METERED DOSE INHALER FORMULATION

被引：16

作者：

HARDY, JG ^{[1
]}

EVERARD, ML ^{[1
]}

COFFINER, M ^{[1
]}

FOSSION, J ^{[1
]}

机构：

[1] PHARMACEUT PROFILES LTD,HIGHFIELDS SCI PK,NOTTINGHAM NG7 2QP,ENGLAND

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1993年 / 6卷 / 01期

关键词：

LUNG DEPOSITION; NACYSTELYN; RADIOLABEL; GAMMA-SCINTIGRAPHY;

D O I：

10.1089/jam.1993.6.37

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The lung deposition of a metered dose inhaler formulation of the mucolytic drug nacystelyn has been assessed in six healthy subjects. The drug particles were radiolabelled with technetium 99m and a dose of 2mg nacystelyn administered to each subject from a single actuation. Images of the deposition were recorded using a gamma camera. Dosing was carried out on two occasions, with and without attachment of a spacer to the actuator. without the spacer, on average, 12.3% of the dose deposited in the lungs. This was reduced to 9.3% when the spacer was used. The distribution of the tracer within the lungs was unaffected by the use of the spacer: 38% peripheral deposition without and 41% with the spacer. The spacer reduced the oropharyngeal deposition from 65.3% to 9.4% of the dose. This study has shown that this formulation can be used to deliver nacystelyn to the lungs in a reproducible manner.

引用

页码：37 / 44

页数：8

共 14 条

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