CONTROL OF ELECTROLYTE TRANSPORT IN THE KIDNEY THROUGH A DOPAMINE-REGULATED AND CAMP-REGULATED PHOSPHOPROTEIN, DARPP-32

被引:16
作者
FRYCKSTEDT, J
MEISTER, B
APERIA, A
机构
[1] ST GORANS UNIV HOSP, DEPT PAEDIAT, S-11281 STOCKHOLM, SWEDEN
[2] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, S-10401 STOCKHOLM 60, SWEDEN
来源
JOURNAL OF AUTONOMIC PHARMACOLOGY | 1992年 / 12卷 / 03期
关键词
D O I
10.1111/j.1474-8673.1992.tb00376.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1 DARPP-32 is a phosphoprotein regulated by dopamine and cAMP. In its phosphorylated form it acts as an inhibitor of protein phosphatase-1, thereby regulating the phosphorylation state of phosphoproteins in the basal ganglia. 2 In the kidney, DARPP-32 has been detected in the medullary thick ascending limb of Henle (mTAL) and, to a lesser degree, in the proximal convoluted tubule by means of immunohistochemistry and in situ hybridization. 3 In single microdissected tubules of rat kidney, Na+, K+-ATPase activity, measured as ouabain-sensitive ATP hydrolysis, has been shown to be inhibited to the same degree by the DA1 agonist fenoldopam, cAMP and a synthesized and phosphorylated DARPP-32 peptide, D32(8-38). 4 It is concluded that the DA1 receptor-mediated inhibition of Na+ transport in the mTAL by dopamine occurs via cAMP accumulation and the phosphoprotein, DARPP-32.
引用
收藏
页码:183 / 189
页数:7
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