MONONUCLEOTIDE REPEATS ARE AN ABUNDANT SOURCE OF LENGTH VARIANTS IN MOUSE GENOMIC DNA

被引：80

作者：

AITMAN, TJ ^{[1
]}

HEARNE, CM ^{[1
]}

MCALEER, MA ^{[1
]}

TODD, JA ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG,OXFORD OX3 9DU,ENGLAND

来源：

MAMMALIAN GENOME | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1007/BF00352326

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsatellite sequences, such as dinucleotide repeats, show a high degree of polymorphism in eukaryotic DNA. These sequences are convenient as genetic markers and can be analyzed by the polymerase chain reaction (PCR). We have assessed the frequency of length variants in 18 mononucleotide repeats in mouse DNA and find that the variability is similar to that reported for dinucleotide repeats. Nine of the 18 repeat sequences (50%) have three or more alleles in the strains tested. Ten of these repeat sequences have been mapped using strain distribution patterns (SDPs) in recombinant inbred (RI) strains.

引用

页码：206 / 210

页数：5

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