BEHAVIORAL-EFFECTS OF THE PUTATIVE D-3 DOPAMINE RECEPTOR AGONIST 7-OH-DPAT IN RELATION TO OTHER D-2-LIKE AGONISTS

被引：179

作者：

DALY, SA ^{[1
]}

WADDINGTON, JL ^{[1
]}

机构：

[1] ROYAL COLL SURGEONS IRELAND, DEPT CLIN PHARMACOL, ST STEPHENS GREEN, DUBLIN 2, IRELAND

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 05期

基金：

英国惠康基金;

关键词：

DOPAMINE D-3 RECEPTORS; 7-OH-DPAT; BEHAVIOR;

D O I：

10.1016/0028-3908(93)90177-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The putative D-3 dopamine receptor agonist 7-OH-DPAT (10 mug/kg, s,c.) reduced spontaneous activity in rats, without inducing yawning; higher doses (0.1-10.0 mg/kg, s.c.) stimulated non-stereotyped sniffing, locomotion and chewing, which were attenuated by the selective D-1 antagonist BW 737C (5.0 mg/kg, s.c.) without release of any atypical behaviours. Low doses of 7-OH-DPAT may act on inhibitory D-3 receptors, while higher doses may act at stimulatory D-3 or other ''D-2-like'' receptors that participate in cooperative but not oppositional interactions with D-1 receptors.

引用

页码：509 / 510

页数：2

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