VACCINATION WITH 2 DIFFERENT VACCINIA RECOMBINANT VIRUSES - LONG-TERM INHIBITION OF SECONDARY VACCINATION

被引：79

作者：

KUNDIG, TM

KALBERER, CP

HENGARTNER, H

ZINKERNAGEL, RM

机构：

[1] Institute of Experimental Immunology, University of Zürich, CH 8091 Zürich

来源：

VACCINE | 1993年 / 11卷 / 11期

关键词：

VACCINIA RECOMBINANT VIRUS; LONG-TERM INHIBITION; SECONDARY VACCINATION;

D O I：

10.1016/0264-410X(93)90079-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

the effects of immunity to vaccina virus on the efficiency of vaccination with a vaccinia recombinant virus were studied. In mice the efficiency and duration of the B-cell response to the recombinant gene product of a second vaccinia recombinant virus were suppressed for more than 9 months, i.e. practically lifelong. Antibody titres against the recombinant gene product were not only lower but also lasted for a shorter time. Thus, immunity to vaccinia virus may influence both the titre and duration of the antibody response induced by a second distinct vaccinia recombinant vaccine.

引用

页码：1154 / 1158

页数：5

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