A FREE-RADICAL ROUTE TO SYN LACTONES AND OTHER PROSTANOID INTERMEDIATES IN ISOPROSTAGLANDIN SYNTHESIS

被引：41

作者：

RONDOT, B ^{[1
]}

DURAND, T ^{[1
]}

GIRARD, JP ^{[1
]}

ROSSI, JC ^{[1
]}

SCHIO, L ^{[1
]}

KHANAPURE, SP ^{[1
]}

ROKACH, J ^{[1
]}

机构：

[1] FLORIDA INST TECHNOL,CLAUDE PEPPER INST AGING & THERAPEUT RES,MELBOURNE,FL 32901

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(00)61401-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The hex-5-enyl radical cyclization methodology was applied to the formation of optical active prostanoid intermediates ($) under bar 7,($) under bar 8,($) under bar 9 with readily available diacetone-D-glucose as starting material. This result should lead to isoprostaglandins, a navel class of arachidonic acid metabolites obtained by a non-cyclooxygenase mechanism involving free radical-catalysed peroxidation of arachidonic acid.

引用

页码：8245 / 8248

页数：4

共 12 条

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