ANTIINFLAMMATORY ACTIVITY OF THE ESSENTIAL OIL OF BUPLEURUM-FRUTICESCENS

被引：102

作者：

MARTIN, S ^{[1
]}

PADILLA, E ^{[1
]}

OCETE, MA ^{[1
]}

GALVEZ, J ^{[1
]}

JIMENEZ, J ^{[1
]}

ZARZUELO, A ^{[1
]}

机构：

[1] UNIV GRANADA, FAC FARM, DEPT FARMACOL, E-18071 GRANADA, SPAIN

来源：

PLANTA MEDICA | 1993年 / 59卷 / 06期

关键词：

BUPLEURUM-FRUTICESCENS; UMBELLIFERAE; ANTIINFLAMMATORY ACTIVITY; ALPHA-PINENE; BETA-CARYOPHYLLENE;

D O I：

10.1055/s-2006-959755

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The essential oil of Bupleurum fruticescens was investigated qualitatively and quantitatively by GC and GC-MS analyses. The anti-inflammatory activity of the whole essential oil and its major components was also investigated in the rat hindpaw edema model induced by carrageenin or by PGE1. The anti-inflammatory activity shown by the essential oil can be attributed to the two major components, alpha-pinene and beta-caryophyllene. In order to know the role of the adrenal glands in the anti-inflammatory activity exerted by the two major components of the essential oil, they were studied against the carrageenin-induced hindpaw edema in adrenolectomized rats. It is concluded that alpha-pinene needs the integrity of the adrenal glands to exert its anti-inflammatory activity, as opposed to beta-caryophyllene which was also active in adrenolectomized animals.

引用

页码：533 / 536

页数：4

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