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GENETICALLY-MODIFIED ANIMALS AND IMMUNODEFICIENCY

被引：25
作者：
YEUNG, RSM [1 ]
PENNINGER, J [1 ]
MAK, TW [1 ]
机构：
[1] AMGEN RES INST,TORONTO,ON,CANADA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 04期
关键词：
D O I：
10.1016/0952-7915(93)90042-Q
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mouse strains with defined genetic defects engineered by the method of targeted gene disruption and homologous recombination have furthered our understanding of immune functions at the single gene level. More importantly, these mutant 'gene knockout' mice are powerful in vivo tools to dissect the complex mechanisms of lymphocyte development and function, complementing our broadening knowledge of congenital and acquired human immunodeficiencies.
引用
收藏
页码：585 / 594
页数：10
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