THE REGULATION OF TRANSAMINATIVE FLUX OF METHIONINE IN RAT-LIVER MITOCHONDRIA

被引：22

作者：

SCISLOWSKI, PWD

PICKARD, K

机构：

[1] Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, Greenburn Road

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1994年 / 314卷 / 02期

关键词：

D O I：

10.1006/abbi.1994.1461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have demonstrated methanethiol production from methionine in isolated rat liver mitochondria and shown how it is affected by other metabolites. The enzymes involved include several transaminases, branched chain 2-oxoacid dehydrogenase, acyl-CoA dehydrogenase, and crotonase. Methanethiol production from methionine in mitochondria isolated from rat liver was increased by 50% after the rats had been given a single injection of glucagon, but was reduced by 25% when the rats had been starved for 24 h. These results indicate the physiological importance of the transaminative pathway of methionine metabolism. (C) 1994 Academic Press, Inc.

引用

页码：412 / 416

页数：5

共 30 条

[1] ALKYLTHIOACETIC ACID (3-THIA FATTY-ACIDS) - A NEW GROUP OF NON-BETA-OXIDIZABLE, PEROXISOME-INDUCING FATTY-ACID ANALOGS .1. A STUDY ON THE STRUCTURAL REQUIREMENTS FOR PROLIFERATION OF PEROXISOMES AND MITOCHONDRIA IN RAT-LIVER [J].