UP-REGULATION OF ICAM-1 EXPRESSION ON HUMAN DERMAL FIBROBLASTS BY IFN-BETA IN THE PRESENCE OF TNF-ALPHA

被引：9

作者：

HORIKOSHI, T

EZOE, K

NAKAGAWA, H

EGUCHI, H

HANADA, N

HAMAOKA, S

机构：

[1] SAPPORO MED UNIV,SCH MED,DEPT PLAST SURG,CHUO KU,SAPPORO,HOKKAIDO 060,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT DERMATOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

FEBS LETTERS | 1995年 / 363卷 / 1-2期

关键词：

IFN-BETA; TNF-ALPHA; ICAM-1; FIBROBLAST;

D O I：

10.1016/0014-5793(95)00299-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unstimulated human fibroblasts show low or undetectable ICAM-1 expression. Interferon-beta (IFN-beta) at concentrations of 10, 100, and 1000 IU/ml in the presence of tumor necrosis factor-alpha (TNF-alpha) significantly increased the ICAM-1 expression of fibroblasts in a dose-dependent manner. Treatment with IFN-beta alone, however, did not up-regulate the ICAM-1 expression. Furthermore the attachment of peripheral blood mononuclear cells (PBMCs) to cytokine-treated fibroblasts was increased. This augmented attachment was partly inhibited by anti-ICAM-1 antibody. These results suggest that IFN-beta and TNF-alpha may cooperatively modulate the attachment of PBMCs in the dermis.

引用

页码：141 / 144

页数：4

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