PERCUTANEOUS PENETRATION OF INDOMETHACIN

被引：17

作者：

ISHIHAMA, H ^{[1
]}

KIMATA, H ^{[1
]}

MIZUSHIMA, Y ^{[1
]}

机构：

[1] ST MARIANNA UNIV,SCH MED,DEPT INTERNAL MED 1,KAWASAKI,KANAGAWA 213,JAPAN

来源：

EXPERIENTIA | 1979年 / 35卷 / 06期

关键词：

D O I：

10.1007/BF01968257

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

14C-Indomethacin (ID) was applied to the skin of guinea-pigs as an ointment. After several applications, the concentration of ID in the skin and muscle under the applied site reached a constant level. The concentration of ID in the muscle as well as the skin may be enough to exert an anti-inflammatory effect. © 1979 Birkhäuser Verlag.

引用

页码：798 / 799

页数：2

共 4 条

[1] SIMULTANEOUS PHARMACOKINETICS OF INDOMETHACIN IN SERUM AND SYNOVIAL-FLUID [J].

EMORI, HW ;

CHAMPION, GD ;

PAULUS, HE .

ANNALS OF THE RHEUMATIC DISEASES, 1973, 32 (05) :433-435

[2] PHYSIOLOGIC DISPOSITION AND METABOLIC FATE OF INDOMETHACIN ANALOGS .1. 1 PARA CHLOROBENZYLIDENYL-5-METHOXY-2-METHYLINDENE-3-ACETIC ACID [J].

HUCKER, HB ;

HOFFMAN, EA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (07) :1049-&

[3]

PAUSE P, 1974, DRUG RES, V24, P1298

[4]

TAKAHASHI H, 1963, YAKUZAIGAKU, V23, P49

← 1 →