ULTRAVIOLET (UV) ABSORPTION AND CIRCULAR-DICHROISM (CD) SPECTRA OF CAPTOPRIL

被引：5

作者：

BRITTAIN, HG

KADIN, H

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey, 08903

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 10期

关键词：

captopril; chirality; circular dichroism; diastereomers; spectra; ultraviolet absorption;

D O I：

10.1023/A:1015907620546

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ultraviolet and circular dichroism spectra of authentic captopril have been obtained, since the reported literature data are inconsistent with those obtained on highly purified material. The UV absorption spectrum consists of a single band maximum at 200 nm, while the CD spectrum consists of a single negative peak located at 210 nm. The CD spectrum of captopril and its other three diastereomers can be explained largely in terms of a summation of the chirality of its individual components, (S)-proline and (2 S)-3-mercapto-2-methylpropionic acid. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：1082 / 1085

页数：4