MECHANISM OF THE FATTY LIVER INDUCED BY CYCLOHEXIMIDE AND ITS REVERSIBILITY BY ADENOSINE

被引：17

作者：

GARCIASAINZ, JA ^{[1
]}

HERNANDEZMUNOZ, R ^{[1
]}

SANTAMARIA, A ^{[1
]}

CHAGOYADESANCHEZ, V ^{[1
]}

机构：

[1] UNIV NACL AUTONOMA MEXICO,FAC MED,DEPT BIOQUIM,MEXICO CITY 20,MEXICO

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 08期

关键词：

D O I：

10.1016/0006-2952(79)90444-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The administration of cycloheximide to fasted rats produced a 2- to 3-fold increase in hepatic triacylglycerols. The antibiotic decreased the serum level of free fatty acids, triacylglycerols and ketone bodies. It also increased the incorporation of radioactive palmitate into liver lipids. It is suggested that an increased uptake of free fatty acids and an altered partition between oxidation and esterification are involved in the formation of fatty liver by this hepatotoxin. The simultaneous administration of adenosine prevented the formation of fatty liver. It is proposed that the effect of the nucleoside may be related to a decrease in the uptake of fatty acids by the liver. © 1979.

引用

页码：1409 / 1413

页数：5

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