CENTROMERES OF MAMMALIAN CHROMOSOMES

被引：231

作者：

WILLARD, HF

机构：

[1] Department of Genetics, Stanford University, Stanford

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0168-9525(90)90302-M

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The centromere is the major cis-acting genetic locus involved in chromosome segregation in mitosis and meiosis. The mammalian centromere is characterized by large amounts of tandemly repeated satellite DNA and by a number of specific centromere proteins, at least one of which has been shown to interact directly with centromeric satellite DNA sequences. Although direct functional assays of chromosome segregation are still lacking, the data are most consistent with a structural and possibly functional role for satellite DNA in the mammalian centromere. © 1990.

引用

页码：410 / 416

页数：7

共 42 条

[1]

BERNAT RL, IN PRESS J CELL BIOL

[2]

Brinkley B.R., 1989, MITOSIS MOL MECHANIS, P77

[3] CENTROMERES OF BUDDING AND FISSION YEASTS [J].