NEUROPEPTIDE Y AND GALANIN ENHANCE THE INHIBITORY EFFECTS OF CLONIDINE ON NOREPINEPHRINE RELEASE FROM MEDULLA-OBLONGATA OF RATS

被引：11

作者：

TSUDA, K ^{[1
]}

GOLDSTEIN, M ^{[1
]}

MASUYAMA, Y ^{[1
]}

机构：

[1] NYU MED CTR,NEW YORK,NY 10016

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 10期

关键词：

Clonidine; Galanin; Medulla oblongata; Neuropeptide Y; Norepinephrine release;

D O I：

10.1093/ajh/3.10.800

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The medulla oblongata is thought to play an important role in the central regulation of blood pressure. Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region. The aim of the present study was to investigate whether NPY and Gal could modulate the presynaptic neuronal mechanisms, especially the α-adrenoceptor function, inhibiting NE release in medulla oblongata. In slices of rat medulla oblongata, clonidine, an α-adrenoceptor agonist, inhibited the NE release elicited by electrical stimulation in a concentration-dependent manner. A combination of clonidine and low concentration of NPY (1 × 10−9mol/L) resulted in an increase in the inhibitory action of clonidine on stimulation-evoked NE release. The inhibitory action of clonidine was also potentiated by Gal (1 × 10−8mol/L) These results indicate the existence of the presynaptic NPY- and Gal-receptors on noradrenergic nerve terminals, which may enhance the presynaptic α-adrenoceptor function to inhibit NE release. This suggests a possible involvement of NPY and Gal in the regulation of sympathetic nerve activity in medulla oblongata. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：800 / 802

页数：3

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