CHRONIC NEURODEGENERATIVE DISEASE ASSOCIATED WITH HTLV-II INFECTION

被引:248
作者
HJELLE, B
APPENZELLER, O
MILLS, R
ALEXANDER, S
TORREZMARTINEZ, N
JAHNKE, R
ROSS, G
机构
[1] UNIV NEW MEXICO, SCH MED, DEPT MICROBIOL, ALBUQUERQUE, NM 87131 USA
[2] LOVELACE BIOMED RES FDN, ALBUQUERQUE, NM USA
[3] CAMBRIDGE SCI, ROCKVILLE, MD USA
[4] PUBL HLTH SERV CLIN, JEMEZ, NM USA
[5] UNITED BLOOD SERV, ALBUQUERQUE, NM USA
关键词
D O I
10.1016/0140-6736(92)90797-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although human T-cell leukaemia virus (HTLV) type I is known to cause a number of diseases, there has been no convincing evidence of pathological changes after infection with the related virus, HTLV-II. We have found an endemic focus of HTLV-II infection among members of an American Indian population in New Mexico, USA. We set out to determine the pathological consequences of HTLV-II infection in this population and identified two sisters (aged 59 and 46 years) with a disease superficially resembling the myeloneuropathy induced by HTLV-I. These women had a syndrome similar to the olivopontocerebellar atrophy variant of multiple system atrophy, and HTLV-II infection was confirmed by western blot and the polymerase chain reaction. Thus, HTLV-II may, like HTLV-I, cause a progressive neurodegenerative disease.
引用
收藏
页码:645 / 646
页数:2
相关论文
共 8 条
  • [1] TROPICAL SPASTIC PARAPARESIS-LIKE ILLNESS OCCURRING IN A PATIENT DUALLY INFECTED WITH HIV-1 AND HTLV-II
    BERGER, JR
    SVENNINGSSON, A
    RAFFANTI, S
    RESNICK, L
    [J]. NEUROLOGY, 1991, 41 (01) : 85 - 87
  • [2] HENEINE W, 1991, NEW ENGL J MED, V324, P565, DOI 10.1056/NEJM199102213240815
  • [3] HTLV-II AND HTLV-I ASSOCIATED MYELOPATHY
    HENEINE, W
    KHABBAZ, RF
    KAPLAN, JE
    [J]. LANCET, 1991, 338 (8772) : 944 - 945
  • [4] INCIDENCE OF HAIRY-CELL LEUKEMIA, MYCOSIS-FUNGOIDES, AND CHRONIC LYMPHOCYTIC-LEUKEMIA IN 1ST KNOWN HTLV-II-ENDEMIC POPULATION
    HJELLE, B
    MILLS, R
    SWENSON, S
    MERTZ, G
    KEY, C
    ALLEN, S
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (03) : 435 - 440
  • [5] HJELLE B, 1991, ARCH PATHOL LAB MED, V115, P440
  • [6] HTLV-II IN PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY
    KIRA, JI
    KOYANAGI, Y
    HAMAKADO, T
    ITOYAMA, Y
    YAMAMOTO, N
    GOTO, I
    [J]. LANCET, 1991, 338 (8758) : 64 - 65
  • [7] DEVELOPMENT AND EVALUATION OF A HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I SEROLOGIC CONFIRMATORY ASSAY INCORPORATING A RECOMBINANT ENVELOPE POLYPEPTIDE
    LILLEHOJ, EP
    ALEXANDER, SS
    DUBRULE, CJ
    WIKTOR, S
    ADAMS, R
    TAI, CC
    MANNS, A
    BLATTNER, WA
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (12) : 2653 - 2658
  • [8] SEGREGATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II INFECTIONS BY ANTIBODY REACTIVITY TO UNIQUE VIRAL EPITOPES
    LIPKA, JJ
    MIYOSHI, I
    HADLOCK, KG
    REYES, GR
    CHOW, TP
    BLATTNER, WA
    SHAW, GM
    HANSON, CV
    GALLO, D
    CHAN, L
    FOUNG, SKH
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (02) : 268 - 272