SELECTIVE FUNCTIONALIZATION OF 2,2'-BITHIOPHENES

被引：45

作者：

KHOR, E

SIU, CN

HWEE, CL

CHAI, S

机构：

来源：

HETEROCYCLES | 1991年 / 32卷 / 09期

关键词：

D O I：

10.3987/COM-91-5812

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective functionalization of the 2,2'-bithiophene molecule is described. Selective alkyl substitution at the 3,3' positions was achieved by sequential bromination of the 3,3' and 5,5' positions followed by debromination at the 5,5' positions. The resultant 3,3'-dibromo-2,2'-bithiophene was transformed via a Grignard reaction to give a series of 3,3'-dialkyl-2,2'-bithiopenes. Finally nitration of the active 5,5' positions gave the corresponding 3,3'-dialkyl-5,5'-dinitro-2,2'-bithiophenes.

引用

页码：1805 / 1812

页数：8

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