EFFECTS OF ANTIBODIES AGAINST OCTREOTIDE IN 2 PATIENTS WITH ACROMEGALY

被引：15

作者：

ORSKOV, H

CHRISTENSEN, SE

WEEKE, J

KAAL, A

HARRIS, AG

机构：

[1] AARHUS UNIV,INST EXPTL CLIN RES,MED RES LABS,DK-8000 AARHUS,DENMARK

[2] SANDOZ PHARMA LTD,DEPT NEUROENDOCRINOL,CH-4002 BASEL,SWITZERLAND

来源：

CLINICAL ENDOCRINOLOGY | 1991年 / 34卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.1991.tb00311.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two patients developed specific IgG antibodies against octreotide after 2-3 years' treatment for acromegaly with this long acting somatostatin analogue. The presence of these antibodies reduced the plasma disappearance rate of total extractable octreotide by 60 and 80% respectively. When compared to that of non-immune acromegalic patients, the plasma half-life of octreotide in these two patients was 300 and 450 vs 110 min in those with no detectable octreotide antibodies. The sole observed consequence of the immunization was a marked prolongation of the interval of maximum GH inhibition from a mean of 5 to 8 and 10 h in the two patients described after octreotide injection.

引用

页码：395 / 398

页数：4

共 9 条

[1] CONTINUOUS SUBCUTANEOUS PUMP INFUSION OF SOMATOSTATIN ANALOG SMS 201-995 VERSUS SUBCUTANEOUS INJECTION SCHEDULE IN ACROMEGALIC PATIENTS [J].

CHRISTENSEN, SE ;

WEEKE, J ;

ORSKOV, H ;

MOLLER, N ;

FLYVBJERG, A ;

HARRIS, AG ;

LUND, E ;

JORGENSEN, J .

CLINICAL ENDOCRINOLOGY, 1987, 27 (03) :297-306

[2]

FUESSL H S, 1987, Alimentary Pharmacology and Therapeutics, V1, P45

[3]

KENDALLTAYLOR P, 1989, LANCET, V2, P859

[4] WICK CHROMATOGRAPHY FOR RAPID AND RELIABLE IMMUNOASSAY OF INSULIN GLUCAGON AND GROWTH HORMONE [J].

ORSKOV, H ;

THOMSEN, HG ;

YDE, H .

NATURE, 1968, 219 (5150) :193-&

[5]

ORSKOV H, 1988, SANDOSTATIN TREATMEN, P83

[6]

PEDERSEN NS, 1979, J IMMUNOL METHODS, V30, P257

[7] INSULIN RESISTANCE IN UREMIC INSULIN-DEPENDENT DIABETICS - EFFECT OF DIALYSIS THERAPY AS ASSESSED BY THE ARTIFICIAL ENDOCRINE PANCREAS [J].

SCHMITZ, O ;

ALBERTI, KGMM ;

ORSKOV, H .

ACTA ENDOCRINOLOGICA, 1984, 105 (03) :371-378

[8] LACK OF ANTIBODY-FORMATION DURING LONG-TERM SUBCUTANEOUS TREATMENT WITH THE SOMATOSTATIN ANALOG OCTREOTIDE IN ACROMEGALY [J].

VANLIESSUM, PA ;

SWINKELS, LM ;

PIETERS, GF ;

ROSS, AA ;

SMALS, AG ;

BENRAAD, TJ ;

KLOPPENBORG, PW .

ACTA ENDOCRINOLOGICA, 1990, 122 (03) :309-312

[9]

1989, LANCET, V2, P541

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