RELATIONSHIP BETWEEN MORPHINE, ASPARTIC-ACID AND L-ASPARAGINASE IN RATS

被引：20

作者：

KOYUNCUOGLU, H

KEYERUYSAL, M

BERKMAN, K

GUNGOR, M

GENC, EM

机构：

[1] Department of Pharmacology and Clinical Pharmacology, Istanbul Medical Faculty, Çapa, Istanbul

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 04期

关键词：

Analgesia; Aspartic acid; Hypoactivity; L-Asparaginase activity; L-Asparaginase administration; Morphine;

D O I：

10.1016/0014-2999(79)90244-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid completely antagonized the effect of morphine. Additionally 500 IU/kg L-asparaginase and 5 or 10 mg/kg morphine were i.v. injected into 56 rats divided into 5 groups. L-Asparaginase, which, in turn, increased motor activity, antagonized the morphine-induced hypoactivity and analgesia. These results support our previous findings. © 1979.

引用

页码：369 / 372

页数：4

共 6 条

[1]

COONEY DA, 1970, ANN REV PHARMACOL, V10, P42

[2] ANTAGONIZING EFFECT OF ASPARTIC-ACID ON MORPHINE WITHDRAWAL AND LEVALLORPHAN-PRECIPITATED ABSTINENCE SYNDROME SIGNS AND ON ASSOCIATED CHANGES IN BRAIN LEVELS OF FREE AMINO-ACIDS IN THE RAT [J].