ANGULAR ANISOTROPY OF H-2 NMR SPECTRAL DENSITIES IN PHOSPHOLIPID-BILAYERS CONTAINING CHOLESTEROL

被引：29

作者：

TROUARD, TP ^{[1
]}

ALAM, TM ^{[1
]}

ZAJICEK, J ^{[1
]}

BROWN, MF ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721

来源：

CHEMICAL PHYSICS LETTERS | 1992年 / 189卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0009-2614(92)85154-3

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

Spin-lattice (R1Z) and quadrupolar order (R1Q) relaxation rates were measured for bilayers of macroscopically oriented 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC-d54) containing cholesterol (1:1 molar ratio), using inversion recovery and broadband Jeener-Broekaert pulse sequences, respectively. Anisotropic deuterium (H-2) NMR spin relaxation data were obtained for the first time along the entire flexible acyl chains of the phospholipid molecules in the liquid-crystalline state. Individual spectral densities J1 (omega(0) and J2 (2omega(0)) were calculated from these relaxation rates, and a strong dependence on the angle theta-between the macroscopic bilayer normal and the static magnetic field was observed. The spectral densities exhibited opposite angular anisotropies, which were explained in terms of a simple rotational diffusion model for the molecular dynamics of membrane lipid constituents.

引用

页码：67 / 75

页数：9

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