INVIVO STUDIES ON THE ENHANCEMENT OF SEROTONIN REUPTAKE BY TIANEPTINE

被引:32
作者
DESIMONI, MG
DELUIGI, A
CLAVENNA, A
MANFRIDI, A
机构
[1] Istituto di Ricerche Farmacologiche 'Mario Negri', Milan
关键词
TIANEPTINE; SEROTONIN; VOLTAMMETRY; INVIVO; 5-HYDROXYINDOLACETIC ACID;
D O I
10.1016/0006-8993(92)90804-I
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The present study investigates the in vivo effects of the serotonin uptake enhancer tianeptine. The serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA) was measured by in vivo voltammetry and carbon fiber electrodes chronically implanted in different brain areas of freely moving rats. Tianeptine (10 mg/kg i.p.) increased extracellular 5-HIAA in the hippocampus and hypothalamus. The interaction between tianeptine and drugs known to interfere with the uptake or release of serotonin (sertraline, buspirone, D-norfenfluramine) was then studied and, to ascertain the in vivo pharmacological relevance of tianeptine's effects, its ability to reduce the serotoninergic syndrome was evaluated. Both the biochemical and behavioral data indicate that in vivo tianeptine's effects on the serotoninergic system are likely to be due to serotonin uptake enhancement.
引用
收藏
页码:93 / 97
页数:5
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