ANTIFUNGAL ANTHRACYCLINE ANTIBIOTICS, SPARTANAMICIN-A AND SPARTANAMICIN-B FROM MICROMONOSPORA SPP

被引：41

作者：

NAIR, MG ^{[1
]}

MISHRA, SK ^{[1
]}

PUTNAM, AR ^{[1
]}

PANDEY, RC ^{[1
]}

机构：

[1] XECHEM INC,NEW BRUNSWICK,NJ 08901

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 11期

关键词：

D O I：

10.7164/antibiotics.45.1738

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Spartanamicins A and B, two antifungal antibiotics, were produced by a culture of Micromonospora spp. strain No. MSU-43097 (ATCC 53803), isolated from a potted soil containing asparagus (Asparagus officinalis L.) plants. The antibiotics were isolated from the mycelial cake using organic solvents. The structures of spartanamicins A and B were determined by spectral and chemical means. Spartanamicin B is more active as an antifungal compound than it's analogue, A. The minimum inhibitory concentration for spartanamicin B on Candida albicans and Aspergillus, Cladosporium, Cryptococcus, Rhodotorula and Staphylococcus spp. ranged from 0.2 to 1 mug/ml. It was not active against Staphylococcus aureus, Escherichia coli and Citrobacter spp. but some strains of S. aureus were sensitive.

引用

页码：1738 / 1745

页数：8

共 15 条

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