SYNTHESIS AND DNA CLEAVING ACTIVITY OF COPPER-COMPLEX OF MACROCYCLIC COMPOUND CONTAINING 1, 10-PHENANTHROLINE

被引：23

作者：

HIRAI, M

SHINOZUKA, K

SAWAI, H

OGAWA, S

机构：

[1] GUNMA UNIV, FAC ENGN, DEPT CHEM, KIRYU, GUNMA 376, JAPAN

[2] OCHANOMIZU UNIV, FAC HOME ECON, DEPT TEXTILES & CLOTHING, TOKYO 112, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 10期

关键词：

D O I：

10.1246/cl.1992.2023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-complexes of 1, 14: 7, 8- diethenotetrapyrido- [2, 1, 6-de: 2', 1', 6'-gh: 2", 1", 6"-kl: 2''', 1''', 6'''-na] [1, 5, 8, 12] tetraaza- [3, 10] dithiocyclotetradecine (SMC) consisting of two 1, 10-phenanthroline molecules bridged by sulfur, was synthesized. Interaction of Cu-SMC with DNA was examined by spectroscopic methods. Cu-SMC binds with DNA and cleaves DNA in the presence of a reducing agent under an aerobic condition.

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页码：2023 / 2026

页数：4

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