SEQUENCE COMPARISON OF OPEN READING FRAMES 2 TO 5 OF LOW AND HIGH VIRULENCE UNITED-STATES ISOLATES OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS

被引:136
作者
MENG, XJ
PAUL, PS
HALBUR, PG
MOROZOV, I
机构
[1] IOWA STATE UNIV,VET MED RES INST,AMES,IA 50011
[2] IOWA STATE UNIV,DEPT MICROBIOL IMMUNOL & PREVENT MED,AMES,IA 50011
[3] IOWA STATE UNIV,COLL VET MED,VET DIAGNOST LAB,AMES,IA 50011
关键词
D O I
10.1099/0022-1317-76-12-3181
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The sequences of ORFs 2 to 5 of five United States (US) porcine reproductive and respiratory syndrome virus (PRRSV) isolates with differing virulence were determined. The nucleotide and deduced amino acid sequences of these isolates were compared with those of other known PRRSV isolates. The amino acid sequence identity between seven US PRRSV isolates was 91-99 % in ORF 2, 86-98 % in ORF 3, 92-99 % in ORF 4 and 88-97 % in ORF 5. The low virulence US isolate had highest sequence variation in ORFs 2 to 4 compared to the other US isolates. A hypervariable region with antigenic potential was identified within the major envelope glycoprotein. Phylogenetic analysis of ORFs 2 to 7 indicated the existence of at least three minor genotypes within the major US genotype. The low virulence US isolate formed a branch distinct from the other US isolates. The results of this study have implications for both the taxonomy of PRRSV and vaccine development.
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页码:3181 / 3188
页数:8
相关论文
共 20 条
[1]  
CHRISTIANSON WT, 1992, AM J VET RES, V53, P485
[2]   ISOLATION OF SWINE INFERTILITY AND RESPIRATORY SYNDROME VIRUS (ISOLATE ATCC VR-2332) IN NORTH-AMERICA AND EXPERIMENTAL REPRODUCTION OF THE DISEASE IN GNOTOBIOTIC PIGS [J].
COLLINS, JE ;
BENFIELD, DA ;
CHRISTIANSON, WT ;
HARRIS, L ;
HENNINGS, JC ;
SHAW, DP ;
GOYAL, SM ;
MCCULLOUGH, S ;
MORRISON, RB ;
JOO, HS ;
GORCYCA, D ;
CHLADEK, D .
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 1992, 4 (02) :117-126
[3]   MOLECULAR CHARACTERIZATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS, A MEMBER OF THE ARTERIVIRUS GROUP [J].
CONZELMANN, KK ;
VISSER, N ;
VANWOENSEL, P ;
THIEL, HJ .
VIROLOGY, 1993, 193 (01) :329-339
[4]   EQUINE ARTERITIS VIRUS IS NOT A TOGAVIRUS BUT BELONGS TO THE CORONAVIRUSLIKE SUPERFAMILY [J].
DENBOON, JA ;
SNIJDER, EJ ;
CHIRNSIDE, ED ;
DEVRIES, AAF ;
HORZINEK, MC ;
SPAAN, WJM .
JOURNAL OF VIROLOGY, 1991, 65 (06) :2910-2920
[5]   NEW OBSERVATIONS ON ANTIGENIC DIVERSIFICATION OF RNA VIRUSES - ANTIGENIC VARIATION IS NOT DEPENDENT ON IMMUNE SELECTION [J].
DOMINGO, E ;
DIEZ, J ;
MARTINEZ, MA ;
HERNANDEZ, J ;
HOLGUIN, A ;
BORREGO, B ;
MATEU, MG .
JOURNAL OF GENERAL VIROLOGY, 1993, 74 :2039-2045
[6]   MOLECULAR CHARACTERIZATION OF THE 3' TERMINUS OF THE SIMIAN HEMORRHAGIC-FEVER VIRUS GENOME [J].
GODENY, EK ;
ZENG, L ;
SMITH, SL ;
BRINTON, MA .
JOURNAL OF VIROLOGY, 1995, 69 (04) :2679-2683
[7]   PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME [J].
GOYAL, SM .
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 1993, 5 (04) :656-664
[8]  
HALBUR PG, 1995, IN PRESS J VET DIAGN
[9]  
HALBUR PG, 1995, IN PRESS VET PATHOLO, V32
[10]   PHYLOGENETIC ANALYSES OF THE PUTATIVE M(ORF-6)-GENE AND N(ORF-7)-GENE OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) - IMPLICATION FOR THE EXISTENCE OF 2 GENOTYPES OF PRRSV IN THE USA AND EUROPE [J].
MENG, XJ ;
PAUL, PS ;
HALBUR, PG ;
LUM, MA .
ARCHIVES OF VIROLOGY, 1995, 140 (04) :745-755