EFFECTS OF ZOTEPINE, HALOPERIDOL AND CLOZAPINE ON MK-801-INDUCED STEREOTYPY AND LOCOMOTION IN RATS

被引：38

作者：

GATTAZ, WF

SCHUMMER, B

BEHRENS, S

机构：

[1] Neurobiology Unit, Central Institute of Mental Health, Mannheim

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1994年 / 96卷 / 03期

关键词：

MK-801; NMDA-RECEPTOR; STEREOTYPIES; ZOTEPINE; HALOPERIDOL; CLOZAPINE;

D O I：

10.1007/BF01294789

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study we compared the effects of the atypical neuroleptic zotepine to haloperidol and clozapine on stereotypies and locomotion induced in rats by the N-methyl-D-aspartate (NMDA) antagonist MK-801. Zotepine caused a dose-dependent reduction of MK-801-induced stereotypies and locomotion. Zotepine at a dosis of 2.5 mg/kg body weight showed a similar effect to 0.25 mg/kg haloperidol in reducing sterotypies and locomotion. Clozapine (5.0 mg/kg) reduced significantly locomotion and non-significantly stereotypies. These results add support to the assumption that MK-801-induced behavior provides an adequate animal model to test the potential efficacy of typical and atypical neuroleptics in the treatment of psychoses.

引用

页码：227 / 232

页数：6

共 19 条

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