USE OF HEPATIC MFO AND BLOOD ENZYME BIOMARKERS IN SAND FLATHEAD (PLATYCEPHALUS-BASSENSIS) AS INDICATORS OF POLLUTION IN PORT PHILLIP BAY, AUSTRALIA

被引：42

作者：

HOLDWAY, DA

BRENNAN, SE

AHOKAS, JT

机构：

[1] Key Centre for Applied and Nutritional Toxicology, Royal Melbourne Institute of Technology (RMIT University), Melbourne

来源：

MARINE POLLUTION BULLETIN | 1994年 / 28卷 / 11期

关键词：

D O I：

10.1016/0025-326X(94)90304-2

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Hepatic ethyoxycoumarin O-deethylase (ECOD) and ethoxyresorufin O-deethylase (EROD) activities, and serum sorbitol dehydrogenase (s-SDH) were measured over 3 years in sand flathead (Platycephalus bassensis) collected from Port Phillip Bay, Australia. Significant enzyme induction generally occurred in regions closest to highly industrial and urbanized areas relative to undeveloped reference areas of the bay. High s-SDH levels were associated with lower hepatic microsomal ECOD and EROD levels. There were no sex differences in liver ECOD or s-SDH in any sampling period, and sex differences in EROD activity,were only significant in September 1990, when males had significantly higher activities than females (47.0 pmol min(-1) mg protein(-1) compared with 28.4 pmol min(-1) mg protein(-1), respectively). Liver EROD activity in sand flathead from Hobsons Bay was positively correlated with total freshwater input, mainly from the Yarra River, suggesting PAHs as a possible cause of the observed induction.

引用

页码：683 / 695

页数：13

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