PROSPECTIVE-STUDY OF LIPOPROTEIN(A) AS A RISK FACTOR FOR ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE IN PATIENTS WITH DIABETES

被引：73

作者：

HIRAGA, T

KOBAYASHI, T

OKUBO, M

NAKANISHI, K

SUGIMOTO, T

OHASHI, Y

MURASE, T

机构：

[1] TORANOMON GEN HOSP,DEPT ENDOCRINOL & METAB,MINATO KU,TOKYO 105,JAPAN

[2] OKINANA MEM INST MED RES,TOKYO,JAPAN

[3] UNIV TOKYO,DEPT BIOSTAT & EPIDEMIOL,TOKYO,JAPAN

来源：

DIABETES CARE | 1995年 / 18卷 / 02期

关键词：

D O I：

10.2337/diacare.18.2.241

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE- To assess whether lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic cardiovascular disease in diabetes. RESEARCH DESIGN AND METHODS- We studied 221 patients with non-insulin-dependent diabetes mellitus (NIDDM) without diabetic complications who were followed for 2.2-3.1 years. Their serum Lp(a) levels were semiquantified by a rapid electrophoretic method that accurately discriminates high from low serum Lp(a) at the 20 mg/dl level. RESULTS- Seven of 105 diabetic patients with a high serum Lp(a) experienced a clinical event related to atherosclerotic cardiovascular disease. This incidence was significantly higher than that of the 110 diabetic patients with a low serum Lp(a). The logistic regression analysis revealed that Lp(a) was an independent risk factor for the event. CONCLUSIONS- Lp(a) is a significant risk factor for atherosclerotic cardiovascular disease in NIDDM.

引用

页码：241 / 244

页数：4

共 14 条

[1] LACK OF ASSOCIATION BETWEEN LIPOPROTEIN (A) CONCENTRATIONS AND CORONARY HEART-DISEASE MORTALITY IN DIABETES - THE WISCONSIN EPIDEMIOLOGIC-STUDY OF DIABETIC-RETINOPATHY [J].